Does Borderlands: The Pre-Sequel run on Steam Deck?

Borderlands: The Pre-Sequel is rated Playable on Steam Deck. It runs, but Valve flags some rough edges — you may need the touchscreen, a community controller layout, or tweaked settings.

Valve's test notes

PC (Windows) system requirements

Minimum

Minimum:
OS *: Windows XP SP3
Processor: 2.4 GHz Dual Core Processor
Memory: 2048 MB RAM
Graphics: NVIDIA GeForce 8500 / ATI Radeon HD 2600
DirectX: Version 9.0
Storage: 13 GB available space
Sound Card: DirectX 9 Compliant
Additional Notes: Other Requirements & Supports: Initial installation requires one time internet connection for Steam authentication; software installations required (included with the game) include Steam Client, directX 9, Microsoft .NET 4 Framework, Visual C++ Redistributable 2005, Visual C++ Redistributable 2008, Visual C++ Redistributable 2010, and AMD CPU Drivers (XP Only/AMD Only). Windows Imaging Component (Windows XP 64-Bit only)

Recommended

Recommended:
OS *: Windows XP SP3/Vista/Win 7/Win 8
Processor: 2.3 GHz Quad Core processor
Memory: 2048 MB RAM
Graphics: NVIDIA GeForce GTX 560 / ATI Radeon HD 5850
DirectX: Version 10
Storage: 20 GB available space
Sound Card: DirectX 9.0 c Compliant

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